Current DNA base editors contain nuclease and DNA deaminase that enables deamination
of cytosine (C) or adenine (A), but no method for guanine (G) or thymine (T) editing is …

Base editors show promise for treating human genetic diseases, but most current systems
use deaminases, which cause off-target effects and are limited in editing type. In this study …

CRISPR-guided DNA base editors (BEs) are potent genome editing tools in biotechnology
and medicine. However, conventional cytosine and adenine BEs can only induce base …

Establishing saturated mutagenesis in a specific gene through gene editing is an efficient
approach for identifying the relationships between mutations and the corresponding …

Base editing techniques were developed for precise base conversion on cellular genomic
DNA, which has great potential for the treatment of human genetic diseases. The …

We recently developed base editing, the programmable conversion of target C: G base pairs
to T: A without inducing double-stranded DNA breaks (DSBs) or requiring homology …

Base editors have substantial promise in basic research and as therapeutic agents for the
correction of pathogenic mutations. The development of adenine transversion editors has …

Although base editors are useful tools for precise genome editing, current base editors can
only convert either adenines or cytosines. We developed a dual adenine and cytosine base …

Adenine base editors (ABEs) composed of an engineered adenine deaminase and the
Streptococcus pyogenes Cas9 nickase enable adenine-to-guanine (A-to-G) single …

Adenine base editors (ABE) are genome-editing tools that have been harnessed to
introduce precise A• T to G• C conversion. However, the low activity of ABE at certain sites …