The biomechanical properties of the brain microenvironment, which is composed of different
neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain …

To highlight the particular needs with respect to modeling the unique and complex
organization of the human brain structure, we reviewed the state-of-the-art in devising brain …

In the brain, neural stem cells (NSC) are tightly regulated by external signals and
biophysical cues mediated by the local microenvironment or “niche.” In particular, the …

In vitro models are invaluable tools for studying cell behavior in a highly controlled setting.
Cell and tissue culture models of the nervous system can be utilized to elucidate …

Myelin is the lipidic insulating structure enwrapping axons and allowing fast saltatory nerve
conduction. In the central nervous system, myelin sheath is the result of the complex …

Glial cells are mechanosensitive, and thus, engineered systems have taken a step forward
to design mechanotransduction platforms in order to impart diverse mechanical stresses to …

The central nervous system (CNS) has a highly complex biophysical and biochemical
environment. Despite decades of intensive research, it is still an enormous challenge to …

With the increasing prevalence of neurodegenerative diseases, improved models of the
central nervous system (CNS) will improve our understanding of neurophysiology and …

Abstract 3D in vitro neural cultures have gained interest in recent years as promising
biomimetic micro‐environments which can regulate cell response to neural guidance cues …

Understanding the mechanisms that govern nervous tissues function remains a challenge.
In vitro two-dimensional (2D) cell culture systems provide a simplistic platform to evaluate …