The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

The concept of “magic bullets”, ie, drugs able to selectively act on target cells, formulated by
Paul Ehrlich more than one century ago, gave rise to the idea of immunotargeting, one of the …

Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a
century ago. They continue to fascinate scientists and the public due to their very high …

Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or
an antibody fragment. Conjugation can be obtained by chemical or genetic engineering …

Most molecular target-based therapeutic research facilities use two basic techniques:
protein-kinase inhibitors and monoclonal antibodies. However, they continue to face …

This review presents only those contributions that have progressed from the bench to the
clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or …

Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific
adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. This loop is important …

The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to
the Sambucus genus, have the characteristic that although being even more active than ricin …

Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a
targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The …

Ribosome-inactivating proteins (RIPs) are enzymes (3.2. 2.22) that possess N-glycosilase
activity that irreversibly inhibits protein synthesis. RIPs have been found in plants, fungi …