Dose delays, dose reductions, and relative dose intensity in patients with cancer who received adjuvant or neoadjuvant chemotherapy in community oncology …

N Denduluri, DA Patt, Y Wang, M Bhor, X Li… - Journal of the National …, 2015 - jnccn.org
Background: A wide variety of myelosuppressive chemotherapy regimens are used for the
treatment of cancer in clinical practice. Neutropenic complications, such as febrile …

Impact of chemotherapy dose intensity on cancer patient outcomes

GH Lyman - Journal of the National Comprehensive Cancer …, 2009 - jnccn.org
Chemotherapy dose intensity represents unit dose of chemotherapy administered per unit
time. Dose intensity can be increased or decreased through altering dose administered, time …

Chemotherapy dose intensity and quality cancer care.

GH Lyman - Oncology (Williston Park, NY), 2006 - europepmc.org
Myelosuppression continues to represent the major dose-limiting toxicity of cancer
chemotherapy. Neutropenia and its complications, including febrile neutropenia, occur most …

Risk and timing of neutropenic events in adult cancer patients receiving chemotherapy: the results of a prospective nationwide study of oncology practice

J Crawford, DC Dale, NM Kuderer, E Culakova… - Journal of the National …, 2008 - jnccn.org
This study was undertaken to describe the relationship between the occurrence and timing
of neutropenic events and chemotherapy treatment in a community-based population of …

Patterns of chemotherapy‐associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study

E Culakova, R Thota, MS Poniewierski… - Cancer …, 2014 - Wiley Online Library
Neutropenic complications remain an important dose‐limiting toxicity of cancer
chemotherapy‐associated with considerable morbidity, mortality, and cost. Risk of the initial …

Neutropenia occurrence and predictors of reduced chemotherapy delivery: results from the INC-EU prospective observational European neutropenia study

R Pettengell, M Schwenkglenks, R Leonard… - Supportive care in …, 2008 - Springer
Goals of work Neutropenia is a life-threatening, dose-limiting toxicity of many chemotherapy
regimens. The goals of this study were to assess the incidence and risk of chemotherapy …

[HTML][HTML] Chemotherapy dose intensity and overall survival among patients with advanced breast or ovarian cancer

N Denduluri, GH Lyman, Y Wang, PK Morrow… - Clinical breast …, 2018 - Elsevier
Background The effects of chemotherapy dose intensity on patient outcomes in advanced
cancer are not well understood. We studied the association between chemotherapy relative …

Management of chemotherapy-induced neutropenia: measuring quality, cost, and value

MA Dinan, BR Hirsch, GH Lyman - Journal of the National Comprehensive …, 2015 - jnccn.org
Treatment-associated neutropenia continues to represent the most common dose-limiting
toxicity of cancer chemotherapy. It often leads to fever and infection, prompting …

First Cycle Risk of Severe and Febrile Neutropenia in Cancer Patients Receiving Systemic Chemotherapy: Results from a Prospective Nationwide Study.

J Crawford, DA Wolff, E Culakova, MS Poniewierski… - 2004 - ashpublications.org
Introduction: Myelosuppression represents the major dose-limiting toxicity of cancer
chemotherapy. This prospective, nationwide study was undertaken to better define risk of …

Impact of neutropenia on delivering planned chemotherapy for solid tumours

S Khan, A Dhadda, D Fyfe… - European journal of …, 2008 - Wiley Online Library
The ability to deliver the planned dose and intensity of chemotherapy (the amount of drug
administered/unit of time) is important for tumour control and survival. In clinical practice …