Increasing evidence in recent years indicates that protein misfolding and aggregation,
leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases …

Accumulation of misfolded proteins is a hallmark of many human diseases, including several
incurable neurological disorders, such as Huntington's disease (HD). In HD, expansion of a …

A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease
and Parkinson's disease share common neuropathology, primarily featuring the presence of …

In Huntington's disease, as in other neurodegenerative diseases, it was initially thought that
insoluble protein aggregates are the toxic species. However, growing evidence implicates …

Accumulation of abnormal proteins occurs in many neurodegenerative diseases including
Huntington's disease (HD). However, the precise role of protein aggregation in neuronal cell …

Huntington's disease (HD) is a complex and severe disorder characterized by the gradual
and the progressive loss of neurons, predominantly in the striatum, which leads to the typical …

Huntington's disease (HD) is a devastating neurodegenerative disorder whose main
hallmark is brain atrophy. However, several peripheral organs are considerably affected and …

Neurodegenerative diseases are characterized by intra-and/or extracellular protein
aggregation and oxidative stress. Intense attention has been paid to whether protein …

Posttranslational modifications can have profound effects on the biological and biophysical
properties of proteins associated with misfolding and aggregation. However, their detection …

Mutations are at the root of many human diseases. Still, we largely do not exactly
understand how they trigger pathogenesis. One, more recent, hypothesis has been that they …