The low frequency of hematopoietic stem and progenitor cells (HSPCs) in human BM has
precluded analysis of the direct biochemical effects elicited by cytokines in these …

Hematopoietic stem cell (HSC) function is tightly regulated by cytokine signaling. Although
phospho-flow cytometry allows us to study signaling in defined populations of cells, there …

Protein phosphorylation is a central mechanism of signal transduction that both positively
and negatively regulates protein function. Large-scale studies of the dynamic …

Hematopoietic stem cells (HSCs) are probably the best-studied adult tissue-restricted stem
cells. Although methods for flow cytometric detection of phosphoproteins in hematopoeitic …

Human hematopoietic stem/progenitor cells (HSC) isolated based upon specific patterns of
CD34 and CD38 expression, despite phenotypically identical, were found to be functionally …

Granulocyte colony-stimulating factor (G-CSF) is used clinically to treat leukopenia and to
enforce hematopoietic stem cell (HSC) mobilization to the peripheral blood (PB). However …

Several growth factors (GFs) that together promote quiescent human hematopoietic stem
cell (HSC) expansion ex vivo have been identified; however, the molecular mechanisms by …

Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of
adult stem cell, and the hematopoietic system has served as a principal model structure of …

Hematopoietic stem cells (HSCs) maintain blood homeostasis and are the functional units of
bone marrow transplantation. To improve the molecular understanding of HSCs and their …

Most hematopoietic stem cells (HSCs) are assumed to reside in the so-called side
population (SP) in adult mouse bone marrow (BM). We report the coexistence of non-SP …