MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Chemotherapy has been widely used in treatment of cancer, both as systemic therapy and
as part of local treatment. Unfortunately, many kinds of cancer are still refractory to …

Chemotherapy is the preferred treatment for malignancies. However, a successful long-term
use of chemotherapy is often prevented by the development of drug resistance. Many …

Drug resistance is a major problem in the treatment of cancer patients. Resistance can
develop after prolonged cycles of chemotherapy or can be present intrinsically in the patient …

Development of drug resistance has considerably limited the efficacy of cancer treatments,
including chemotherapy and targeted therapies. Hence, understanding the molecular …

Drug resistance remains a major problem in the treatment of cancer patients for both
conventional chemotherapeutic and novel biological agents. Intrinsic or acquired resistance …

Recently, microRNAs (miRNAs) have received increasing attention in the field of cancer
research. miRNAs play important roles in many normal biological processes; however, the …

Chemo-resistance, which is the main obstacle in cancer therapy, is caused by the onset of
drug-resistant cells in the heterogeneous cell population in cancer tissues. MicroRNAs …

Chemoresistance is one of the major hurdles to overcome for the successful treatment of
breast cancer. At present, there are several mechanisms proposed to explain drug …

Despite substantial progress in understanding the cancer signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …