[HTML][HTML] Alpha-fetoprotein as a Shuttle for Medicines

VN Pak - pharmafocusasia.com
Alpha-fetoprotein (AFP) delivers ligands to monocytes/macrophages that regulate the
immune system activity. AFP or AFP-drugs can be used to treat autoimmune diseases, while …

The use of alpha-fetoprotein for the treatment of autoimmune diseases and cancer

VN Pak - Therapeutic delivery, 2018 - Taylor & Francis
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated
endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha …

Alpha-Fetoprotein Binds Toxins and Can Be Used to Treat Cancer

VN Pak - Medical Research Archives, 2022 - esmed.org
The inefficiency of the immune system to kill cancer cells leads to the disease. Like in
pregnancy, oncofetal proteins counteract the immune attack. Alpha-fetoprotein is an …

Human α-fetoprotein (AFP) causes a selective down regulation of monocyte MHC class II molecules without altering other induced or noninduced monocyte markers …

K Laan-Pütsep, H Wigzell, P Cotran, M Gidlund - Cellular immunology, 1991 - Elsevier
Human α-fetoprotein (AFP) purified from human amniotic fluid was investigated for its effect
on human monocytoid cell lines, including U 937 cells with established subclones. The …

Alpha-fetoprotein: Immunomodulation in autoimmune diseases during pregnancy and puerperium stages

GJ Mizejewski - GSC Biological and Pharmaceutical Sciences, 2022 - gsconlinepress.com
Alpha-fetoprotein (AFP) has long been associated with regulation and modulation of the
immune system in a variety of mammals. In the last several decades, AFP has been linked to …

[PDF][PDF] Alpha-Fetoprotein as an Immunoregulator and Immune Response Modifier: Historical Background and Current Update

GJ Mizejewski - Journal of Immunology Research & Reports. SRC …, 2022 - researchgate.net
The various immunological roles of human alpha-fetoprotein (HAFP) and its correlation with
hepatomas, ie, hepatocellular carcinomas (HCCs), are not always addressed together in the …

Alpha-fetoprotein-mediated immune tolerance and its reversal

VN Pak, NN Belyaev - Alpha-fetoprotein: functions and clinical …, 2016 - elibrary.ru
Alpha-fetoprotein (AFP) serves as a shuttle delivery protein to the AFP receptorpositive
embryo and cancer cells. By delivering nutrients through receptor-mediated endocytosis …

More than a tumor marker… a potential role for alpha-feto protein in inflammatory bowel disease

EA Linson, SB Hanauer - Inflammatory bowel diseases, 2019 - academic.oup.com
Background Human alpha-fetoprotein (hAFP) is a glycoprotein derived from the gut
entoderm and expressed sequentially by cells of the yolk sac, fetal liver, and gastrointestinal …

Significance of alpha-fetoprotein in the development of novel therapeutic agents

XW Wang, H Xie - Drugs Fut, 1999 - access.portico.org
During the past 10 years, progress in protein research has been impressive, including
investigation in isolation, purification, structure determination and synthesis. Many of these …

Alpha-Fetoprotein: A Revolutionary Anti-Cancer Drug

VN Pak - Medical Research Archives, 2023 - esmed.org
Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The
protein serves two critical functions simultaneously: it delivers nutrients to growing embryo …