Transcriptional and Posttranscriptional Regulations of the HLA-G Gene

EC Castelli, LC Veiga-Castelli, L Yaghi… - Journal of …, 2014 - Wiley Online Library
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

The genetic structure of 3′ untranslated region of the HLA-G gene: polymorphisms and haplotypes

EC Castelli, CT Mendes-Junior, NHS Deghaide… - Genes & …, 2010 - nature.com
The HLA-G gene is predominantly expressed at the maternal–fetal interface. It has been
associated with maternal–fetal tolerance and in the inhibition of cytotoxic T lymphocyte and …

The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability

P Rousseau, M Le Discorde, G Mouillot, C Marcou… - Human immunology, 2003 - Elsevier
Human leukocyte antigen (HLA)-G molecules are generated by an alternative splicing of the
primary transcript of the gene and display specialized function in regulating the immune …

Polymorphism in the regulatory region located more than 1.1 kilobases 5′ to the start site of transcription, the promoter region, and exon 1 of the HLA-G gene

TVF Hviid, S Sørensen, N Morling - Human immunology, 1999 - Elsevier
The non-classic Human Leucocyte Antigen class Ib molecule, HLA-G, is expressed on the
invasive, extra-villous cytotrophoblast in human placenta. HLA-G protects against natural …

Non‐classical transcriptional regulation of HLA‐G: an update

P Moreau, S Flajollet… - Journal of cellular and …, 2009 - Wiley Online Library
Introduction• HLA‐G gene promoter region: regulatory sites and binding factors‐The atypical
proximal promoter region of the HLA‐G gene among classical HLA class I genes‐Alternative …

HLA-G unique promoter region: functional implications

C Solier, V Mallet, F Lenfant, A Bertrand, A Huchenq… - Immunogenetics, 2001 - Springer
In contrast to the highly polymorphic HLA class Ia genes that exhibit a broad somatic tissue
distribution, the restricted constitutive expression of HLA-G to trophoblast and a subset of …

[HTML][HTML] Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

EA Donadi, EC Castelli, A Arnaiz-Villena… - Cellular and molecular …, 2011 - Springer
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

A Comprehensive Study of Polymorphic Sites along the HLA-G Gene: Implication for Gene Regulation and Evolution

EC Castelli, CT Mendes-Junior… - Molecular biology …, 2011 - academic.oup.com
HLA-G molecule plays an important role on immune response regulation and has been
implicated on the inhibition of T and natural killer cell cytolytic function and inhibition of …

HLA-G expression is a fundamental prerequisite to pregnancy

R Rizzo, L Melchiorri, M Stignani, OR Baricordi - Human immunology, 2007 - Elsevier
Human leukocyte antigen-G (HLA-G) is thought to play a key role in implantation by
controlling trophoblast invasion and maintaining a local immunosuppressive state. The …

The HLA-G gene is expressed at a low mRNA level in different human cells and tissues

M Onno, T Guillaudeux, L Amiot, I Renard, B Drenou… - Human immunology, 1994 - Elsevier
Recently, HLA-G transgenic mice were shown to exhibit transgene transcription in several
extraembryonic tissues. To determine whether HLA-G mRNAs are also expressed in other …