Spermidine has been known to inhibit the production of pro-inflammatory cytokines.
However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis …

Background Spermidine (SPD) is a natural polyamine that shows beneficial effects on
osteoarthritis (OA). However, the effect of SPD on cartilage inflammation remains unknown …

Osteoarthritis (OA), a degenerative disorder, is considered to be one of the most common
forms of arthritis. Limonin (Lim) is extracted from lemons and other citrus fruits. Limonin has …

The aim of the current study was to explore the role of Resveratrol (Res) in osteoarthritis
(OA) and its underlying mechanism. Reverse transcription‑quantitative polymerase chain …

Abstract Background Interleukin‐1β (IL‐1β) is involved in osteoarthritis pathogenesis and
mediates a series of toxic processes including the production of matrix metalloproteinase …

Purpose Spermidine (SPD) is a naturally occurring polyamine. In this study, we examined
the role and possible mechanism of SPD in collagen-induced arthritis (CIA) mice. Materials …

Osteoarthritis (OA) is one of the most common degenerative diseases, ultimately leading to
long-term joint pain and severe articular malformation. Controlling local chronic …

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation
and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been …

As a degenerative disease, the pathogenesis and treatment of osteoarthritis (OA) are still
being studied. The prevailing view is that articular cartilage dysfunction plays an essential …

Osteoarthritis (OA) is a common chronic joint disease, the etiology of which is complex.
Disturbance to proinflammatory and anti‑inflammatory signaling pathways is a major cause …