Strategies for treating idiopathic pulmonary fibrosis

RM Du Bois - Nature reviews Drug discovery, 2010 - nature.com
Idiopathic pulmonary fibrosis (IPF) is the most common and most lethal diffuse fibrosing lung
disease, with a mortality rate that exceeds that of many cancers. Recently, there have been …

Idiopathic pulmonary fibrosis: recent advances on pharmacological therapy

P Spagnolo, TM Maher, L Richeldi - Pharmacology & therapeutics, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal of the idiopathic interstitial
pneumonias with an estimated 5-year survival of approximately 20%. In the last two decades …

[HTML][HTML] A review of current and novel therapies for idiopathic pulmonary fibrosis

R Rafii, MM Juarez, TE Albertson… - Journal of thoracic …, 2013 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressively fibrotic interstitial lung disease that is
associated with a median survival of 2-3 years from initial diagnosis. To date, there is no …

Idiopathic pulmonary fibrosis: pathobiology of novel approaches to treatment

TM Maher - Clinics in chest medicine, 2012 - chestmed.theclinics.com
Idiopathic pulmonary fibrosis is a nonmalignant disease, yet it carries a prognosis akin to, or
even worse than, many cancers. Until recently, lung transplantation has been the only …

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report

TS Blackwell, AM Tager, Z Borok, BB Moore… - American journal of …, 2014 - atsjournals.org
The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be
approximately 3 years from the time of diagnosis, underscoring the lack of effective medical …

Pharmacological treatment of idiopathic pulmonary fibrosis: current approaches, unsolved issues, and future perspectives

M Kreuter, F Bonella, M Wijsenbeek… - BioMed research …, 2015 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a devastating condition with a 5‐year survival of
approximately 20%. The disease primarily occurs in elderly patients. IPF is a highly …

The management of patients with idiopathic pulmonary fibrosis

P Spagnolo, A Tzouvelekis, F Bonella - Frontiers in medicine, 2018 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF), the most common form of fibrosing idiopathic interstitial
pneumonia, is an inexorably progressive disease with a 5-year survival of~ 20%. In the last …

Update on therapeutic management of idiopathic pulmonary fibrosis

A Tzouvelekis, F Bonella… - Therapeutics and clinical …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive diffuse parenchymal lung
disease of unknown origin, with a mortality rate exceeding that of many cancers. The …

Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years

G Raghu - European Respiratory Journal, 2017 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. A major
breakthrough in treatment came when, after decades of clinical trials which failed to identify …

Current and future treatment landscape for idiopathic pulmonary fibrosis

F Bonella, P Spagnolo, C Ryerson - Drugs, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) remains a disease with poor survival. The pathogenesis
is complex and encompasses multiple molecular pathways. The first-generation antifibrotics …