Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA)
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …

The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Background Osteoarthritis (OA) is the most orthopedic condition. The pattern of gene
expression and the transcription factors that exert control of chondrogenesis have been …

The disabling degenerative disease osteoarthritis (OA) is prevalent among the global
population. Articular cartilage degeneration is a central feature of OA; therefore, a better …

Objectives This study aimed to identify circulating microRNA (miRNA) signatures in knee
synovial fluid (SF) from early-stage and late-stage knee osteoarthritis (OA) patients. Methods …

Objective Articular cartilage is an avascular tissue with precise polarity and organization
comprising 3 distinct functional zones: the surface, middle, and deep zones. Each zone has …

Objective To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a
functional role in cartilage homeostasis. Methods The expression of miRNAs was measured …

Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint.
The relative involvement of each tissue, and their interactions, add to the complexity of OA …

Background Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the
articular cartilage due to environmental, mechanical and genetic components. The genetics …

Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and
environmental factors. Alterations in the normal pattern of chondrocyte gene control in …