Rationale: Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the
progression of human atherosclerosis. However, definitive cell type–specific causation …

High levels of reactive oxygen species (ROS) are observed in chronic human diseases such
as obesity, type 2 diabetes, atherosclerosis, and cardiovascular diseases. In addition to the …

Rationale—Mitochondrial oxidative stress (mitoOS) has been shown to be increased in
various cell types in human atherosclerosis and with aging. However, the role of cell type …

Inflammation is a key process in metazoan organisms due to its relevance for innate defense
against infections and tissue damage. However, inflammation is also implicated in …

Background Oxidative stress associated with cardiovascular disease (CVD) risk factors
contributes to disease development. However, less is known whether specific subcellular …

Macrophages are pivotal in the initiation and development of atherosclerotic cardiovascular
diseases. Recent studies have reinforced the importance of mitochondria in metabolic and …

Background—Coronary atherosclerotic disease remains the leading cause of death in the
Western world. Although the exact sequence of events in this process is controversial …

Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …

Atherosclerotic disease remains a leading cause of death in westernized societies, and
reactive oxygen species (ROS) play a pivotal role in atherogenesis. Mitochondria are the …

Mitochondrial-derived reactive oxygen species (mtROS) is one of the major sources of
cellular ROS, and excessive mtROS is associated with atherosclerosis progression in both …