There is compelling evidence that senescent cells, through the senescence-associated
secretory phenotype (SASP), can promote malignant transformation and invasion …

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …

Inflammation underlies most age-related diseases, including cancer, but the etiology is
poorly understood. One proposed factor is the presence of senescent cells, which increase …

Cellular senescence, a state of sustained cell cycle arrest, has been identified as an
important anti-tumor barrier. Senescent cells secrete various growth factors and cytokines …

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and
oncogenes. However, while arrested, senescent cells secrete a variety of proteins …

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

Abstract Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of
non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun …

Keratinocyte replicative senescence has an important role in time-dependent changes of the
epidermis, a tissue with high turnover. Senescence encompasses growth arrest during …

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …

Senescent cells accumulate in different organs and develop a senescence‐associated
secretory phenotype (SASP), associated with the development of age‐related pathologies …