The role of PPARγ in prostate cancer development and progression

A Hartley, I Ahmad - British Journal of Cancer, 2023 - nature.com
Advanced and metastatic prostate cancer is often incurable, but its dependency on certain
molecular alterations may provide the basis for targeted therapies. A growing body of …

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ as a Novel Target for Prostate Cancer

MR Smith, PW Kantoff - Investigational new drugs, 2002 - Springer
Peroxisome proliferator activatedreceptor-gamma (PPARγ) is a memberof the nuclear
receptor superfamily ofligand-activated transcription factors. PPARγ is expressed at high …

Approaches to understanding the importance and clinical implications of peroxisome proliferator‐activated receptor gamma (PPARγ) signaling in prostate cancer

M Jiang, SB Shappell… - Journal of cellular …, 2004 - Wiley Online Library
The development and maintenance of the prostate are dependent upon a complex series of
interactions occurring between the epithelial and stromal tissues (Hayward and Cunha …

Peroxisome proliferator‐activated receptor gamma controls prostate cancer cell growth through AR‐dependent and independent mechanisms

CC Elix, MM Salgia, M Otto‐Duessel… - The …, 2020 - Wiley Online Library
Background Prostate cancer (PC) remains a leading cause of cancer mortality and the most
successful chemopreventative and treatment strategies for PC come from targeting the …

The role of peroxisome proliferator-activated receptor gamma in prostate cancer

C Elix, SK Pal, JO Jones - Asian journal of andrology, 2018 - journals.lww.com
Despite great progress in the detection and treatment of prostate cancer, this disease
remains an incredible health and economic burden. Although androgen receptor (AR) …

Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma

GP Collett, AM Betts, MI Johnson, AB Pulimood… - Clinical Cancer …, 2000 - AACR
Peroxisome proliferator-activated receptor (PPAR) α is a member of the nuclear receptor
superfamily of ligand-activated transcription factors. PPARα is activated by peroxisome …

Differential peroxisome proliferator-activated receptor-γ isoform expression and agonist effects in normal and malignant prostate cells

V Subbarayan, AL Sabichi, J Kim, N Llansa… - … Biomarkers & Prevention, 2004 - AACR
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is being studied intensively for its role
in carcinogenesis and in mediating the effects of prostate cancer treatment and prevention …

Down-regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor γ in human prostate cancer

J Hisatake, T Ikezoe, M Carey, S Holden, S Tomoyasu… - Cancer research, 2000 - AACR
The peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear
receptor superfamily. Recent studies found that ligand-activated PPARγ regulated …

Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer

S Sikka, L Chen, G Sethi, AP Kumar - PPAR research, 2012 - Wiley Online Library
The peroxisome proliferator‐activated receptor‐gamma (PPARγ) is a member of the
hormone‐activated nuclear receptor superfamily. PPARγ can be activated by a diverse …

Peroxisome Proliferator‐Activated Receptor‐γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer

M Matsuyama, R Yoshimura - PPAR research, 2008 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐γ (PPAR)‐γ is a ligand‐activated transcriptional
factor belonging to steroid receptor superfamily. PPAR‐γ plays a role in both adipocyte …