The placenta is an essential organ that is formed during pregnancy and its proper
development is critical for embryonic survival. While several animal models have been …

A critical transition occurs near mid-gestation of mammalian pregnancy. Prior to this
transition, low concentrations of oxygen (hypoxia) signaling through Hypoxia Inducible …

Transcription factors orchestrate the development of extraembryonic tissues. Because
placental hypoxia likely plays an important role in both normal and abnormal placentation …

Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial
response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple …

Placental hypoxia is causally implicated in fetal growth restriction and preeclampsia, with
both occurring more frequently at high altitude (> 2700 m; HA). The nuclear transcription …

Placental hypoxia likely plays an important role in both normal placental development and
pathology. Yet, the molecular mechanisms of hypoxia signaling in this organ are virtually …

Preeclampsia and intrauterine growth restriction (IUGR) are pregnancy-specific disorders
that share a common pathophysiology. Hypoxia-inducible factor-1α (HIF-1α) is a …

Insufficient remodeling of uterine arteries causes pregnancy‐related diseases, including
fetal growth restriction and preeclampsia. In these situations, reduced maternal blood flow in …

During early pregnancy, placentation occurs in a relatively hypoxic environment which is
essential for appropriate embryonic development. Intervillous blood flow increases at …

Placental development initially occurs in a low-oxygen (O 2) or hypoxic environment. In this
report we show that two hypoxia-inducible factors (HIFs), HIF1α and HIF2α, are essential for …