Genome-wide association studies (GWASs) have revealed substantial genetic components
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …

Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the
genome, and often highly polymorphic. The high mutation rate of TRs, which can be orders …

A problem of 'missing heritability'has been identified following recent genome-wide
association (GWA) studies of single nucleotide polymorphisms (SNPs) associated with …

Tandem repeat expansions (TREs) can cause neurological diseases but their impact in
schizophrenia is unclear. Here we analyzed genome sequences of adults with …

Neuropsychiatric disorders are complex conditions with poorly defined neurobiological
bases. In recent years, there have been significant advances in our understanding of the …

Objectives Genomic copy number variations (CNVs) are a major form of variation in the
human genome and play an etiologic role in several neuropsychiatric diseases. Tandem …

Genome-wide association studies (GWAS) have been the focus of considerable effort in
psychiatry. These efforts have markedly increased knowledge of the genetic basis of …

Family history, which includes both common environmental and genetic effects, is
associated with an increased risk for many neuropsychiatric diseases. Investigators have …

Whole genome associations offer a new and powerful paradigm for the genetic analysis of
psychiatric disease. However, if they fail to identify risk variants, it is important that we …

Genetic etiology plays at least a partial role in most psychiatric disorders. Consistently
replicated linkage and association findings of psychiatric disorders are, however, rare …