The emerging field of nuclear eIF research has yielded many surprises and led to the
dissolution of some dogmatic/ideological viewpoints of the place of translation in the …

In eukaryotic cells, protein synthesis is a complex and multi-step process that has several
mechanisms to start the translation including cap-dependent and cap-independent initiation …

Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA
and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall …

A key regulatory step in translation is initiation, or the recruitment of the translational
machinery to the 5′ end of mRNA. The 5′ terminus of most mRNAs is demarcated by a …

The eukaryotic translation initiation factor eIF 4E is a potent oncogene. Although eIF 4E has
traditional roles in translation initiation in the cytoplasm, it is also found in the nucleus …

This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical
node in an RNA regulon that impacts nearly every stage of cell cycle progression …

A central issue in the study of neoplastic transformation is to understand how proto-
oncogene products deregulate normal processes of cell growth and differentiation; an …

Translational control has a key role in regulating cell growth. The mRNA binding translation
factors (eIF4s) selectively modulate the translation of different mRNAs based on their …

The eukaryotic translation initiation factor eIF4E is a critical modulator of cellular growth with
functions in the nucleus and cytoplasm. In the cytoplasm, recognition of the 5′ m7G cap …

The eukaryotic translation initiation factor eIF4E is overexpressed in many human
malignancies where it is typically a harbinger of poor prognosis. eIF4E is positioned as a …