The neurotrophins are best known for their ability to support neuronal survival and
differentiation, but a role in synapse formation and plasticity has recently emerged. For …

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …

Neurotrophic factors are traditionally viewed as secretory proteins that regulate long-term
survival and differentiation of neurons. The role of neurotrophic factors in the structural …

While it has now been well accepted that neurotrophins play an important role in synapse
development and plasticity, the specific effects of each neurotrophin on different populations …

It has been suggested that long-term modifications of synaptic transmission constitute the
foundation of the processes by which information is stored in the central nervous system. A …

The central nervous system requires the proper formation of exquisitely precise circuits to
function properly. These neuronal circuits are assembled during development by the …

The neurotrophin hypothesis proposes that neurotrophins participate in activity-induced
modification of synaptic transmission. Increasingly, evidence indicates that the synthesis …

A number of recent results suggest that neurotrophins play an important role in early
development as well as in the later, activity-dependent processes important for the final …

Neurotrophins, secreted in an activity-dependent manner, are thought to be involved in the
activity-dependent refinement of synaptic connections. Here we demonstrate that in …