There is a vital need to understand mechanisms contributing to susceptibility to depression
to improve treatments for the 11% of Americans who currently suffer from this debilitating …

Depression is one of the most common neuropsychiatric disorders in the world. While
conventional pharmaceutical therapy targets monoaminergic pathway dysfunction, it has not …

Abstract T helper 17 (Th17) cells have recently been implicated in depression, which adds to
the list of several other diseases of the central nervous system (CNS) that are already known …

Abstract T helper 17 (Th17), a distinct subset of CD4+ T cells with IL-17 as their major
cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases …

T‐helper 17 (Th17) cells are a new lineage of CD4+ T cells that are characterized by their
production of interleukin‐17A (IL‐17A). Recent studies show that these cells can also …

Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellular
pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature …

In 2005 a newly discovered T helper cell subset that secreted interleukin (IL)-17 became the
center of attention in immunology. Initial studies painted Th17 cells as the culprit for …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Autoimmunity results from the dysregulation of the immune system leading to tissue
damage. Th1 and Th17 cells are known to be cellular mediators of inflammation in …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) have been broadly
linked to the pathogenesis of multiple autoimmune diseases. In the few short years since the …