Efficient DNA repair is critical for cell survival following exposure to DNA topoisomerase I
(Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic …

DNA topoisomerase I (Top1) generates transient DNA single-strand breaks via the formation
of cleavage complexes in which the enzyme is linked to the 3′-phosphate of the cleavage …

Irinotecan and topotecan are derivatives of the naturally occurring cytotoxic compound
camptothecin that are used in the treatment of patients with colorectal cancer, either as …

Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

Reversible topoisomerase I (Top1)-DNA cleavage complexes are the key DNA lesion
induced by anticancer camptothecins (CPTs)(eg topotecan and irinotecan) as well as …

Reversible topoisomerase I (Top1)-DNA cleavage complexes are the key DNA lesion
induced by anticancer camptothecins (eg topotecan and irinotecan) as well as structurally …

Camptothecins demonstrate a broad spectrum of antitumor activity. Although they are known
to trap DNA topoisomerase I on DNA, form cleavable complexes, and generate DNA breaks …

Camptothecin (CPT) class of compounds has been demonstrated to be effective against a
broad spectrum of tumors. Their molecular target has been firmly established to be human …

Camptothecins selectively target topoisomerase I (Top1) by trapping the catalytic
intermediate of the Top1-DNA reaction, the cleavage complex. Hence, camptothecins …

Topoisomerase I (TOP1) inhibitors applied in cancer therapy such as topotecan and
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …