Background Cancer recurrence is regulated by a variety of factors, among which is the
material of dying tumor cells; it is suggested that remaining after anti-cancer therapy tumor …

Tumor repopulation during therapy is an important cause of treatment failure. Strategies to
overcome repopulation are arising in parallel with advances in the comprehension of …

Chronic inflammation often precedes malignant transformation and later drives tumor
progression. Likewise, subversion of the immune system plays a role in tumor progression …

The HMGB1 protein has multiple functions in tumor biology and can act both as a
transcription factor and as a cytokine. HMGB1 is released during cell death, and in our …

Background: Exogenous HMGB1 plays a vital role in tumor recurrence, and HMGB1 is
ubiquitous in the tumor microenvironment. However, the mechanism of action is still unclear …

High mobility group box 1 (HMGB1) is an extremely versatile protein that is located
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …

Background The response of breast cancer patients to neoadjuvant chemotherapy (NCT) is
highly heterogeneous, and reliable predictive instruments remain to be defined. High …

High mobility group box 1 (HMGB1) is one of the recently defined damage-associated
molecular pattern molecules, passively released from necrotic cells and secreted by …

Background HMGB1 is a highly conserved nuclear protein widely expressed in mammalian
cells. This study aimed to comprehensively investigate the roles and mechanisms of HMGB1 …

Heat shock protein (Hsp)–peptide complexes purified from tumors can prime the immune
system against tumor antigens, but how they contribute to the generation of immune …