Background The liver plays a central role in the maintenance of homeostasis and health in
general. However, there is substantial inter-individual variation in hepatic gene expression …

Background DNA methylation is an important epigenetic control mechanism that has been
shown to be associated with gene silencing through the course of development, maturation …

Background & Aims Epigenetic mechanisms might be involved in the regulation of liver
enzyme level. We aimed to identify CpG sites at which DNA methylation levels are …

The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …

This study aimed to elucidate the effects of maternal undernutrition (MUN) on epigenetic
modification of hepatic genes in Japanese Black fetal calves during gestation. Using a …

Genome-wide association studies (GWAS) have identified numerous genetic variants in the
human genome associated with diseases and traits. Nevertheless, for most loci the …

A high-fat (HF) diet is associated with progression of liver diseases. To illustrate genome-
wide landscape of DNA methylation in liver of rats fed either a control or HF diet, two …

Background DNA methylation and histone deacetylation are epigenetic mechanisms that
play major roles in eukaryotic gene regulation. We hypothesize that many genes in the …

The discovery of expression quantitative trait loci (“eQTLs”) can help to unravel genetic
contributions to complex traits. We identified genetic determinants of human liver gene …

To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …