Background Inorganic nitrate and nitrite have emerged as alternative substrates for nitric
oxide (NO) generation in the gastrointestinal tract, and have shown to be protective against …

Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
chronic inflammatory disorders of the intestinal tract with excessive production of cytokines …

Nitric oxide (NO) synthesis is up-regulated in inflammatory bowel disease. However, its role
in the pathophysiology of this condition is controversial. The aims of this study were to …

Background: Different authors have postulated both toxic and protective effects for nitric
oxide (NO) in the pathophysiology of active inflammation. Aim: To examine the role of NO …

BACKGROUND Studies using inhibitors of nitric oxide synthase (NOS) to date are
inconclusive regarding the role of inducible NOS (iNOS) in intestinal inflammation. AIMS (1) …

BACKGROUND Oxidative and nitrosative stress have been implicated in the pathogenesis
of inflammatory bowel diseases. AIMS To study the role of nitric oxide (NO) derived from …

There is an abundance of evidence that nitric oxide plays a critical role in regulating several
components of gastrointestinal mucosal defense. Suppression of nitric oxide synthesis …

The role of nitric oxide in gut inflammation was evaluated by comparing the effects of
selective or nonselective inhibitors of nitric oxide synthase (NOS). Aminoguanidine, a …

It has been confusing as to what roles nitric oxide (NO) has in different physiological and
pathological mechanisms in various diseases. In the gastrointestinal tract, NO can be either …

Inflammation of the intestinal tract remains a very serious concern in the clinical setting.
Unfortunately, to date, the mechanisms underlying many inflammatory conditions such as …