Bifunctional enzymes, which contain two domains with opposing enzymatic activities, are
widely distributed in bacteria, but the regulatory mechanism (s) that prevent futile cycling are …

Heme-based sensor proteins are used by organisms to control signaling and physiological
effects in response to their gaseous environment. Globin-coupled sensors (GCS) are oxygen …

Bacteria use the second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) to
control biofilm formation and other key phenotypes in response to environmental signals …

Heme-regulated phosphodiesterase from Escherichia coli (Ec DOS) is a gas-sensor enzyme
that hydrolyzes cyclic dinucleotide-GMP, and it is activated by O 2 or CO binding to the Fe (II) …

Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a second messenger that
modulates bacterial cellular processes, including biofilm formation. While proteins …

Bacteria utilize heme proteins, such as globin coupled sensors (GCSs), to sense and
respond to oxygen levels. GCSs are predicted in almost 2000 bacterial species and consist …

Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP) is a heme-based
O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic …

The second messenger bis (3′, 5′)-cyclic dimeric guanosine monophosphate (c-di-GMP)
regulates numerous important physiological functions in bacteria. In this study, we identified …

Bacteria sense their environment to alter phenotypes, including biofilm formation, to survive
changing conditions. Heme proteins play important roles in sensing the bacterial gaseous …

The discovery of the globin-coupled sensor (GCS) family of haem proteins has provided new
insights into signalling proteins and pathways by which organisms sense and respond to …