This chapter contains sections titled: Sources of Variability The Standard Approach The
Population Approach Population Versus Standard Approach: An Example Pharmacokinetic …

This bibliography lists all published methodological works (statistical methodology,
implementation methodology, review papers, descriptions of software) in the area of …

Serum concentrations of a drug under development were obtained from an animal
pharmacokinetic study using the one sample per animal design, and analyzed using the …

A simulation study was carried out to determine the impact of various design factors on the
accuracy and precision with which population pharmacokinetic parameters are estimated in …

Single response population (1 sample/animal) simulation studies were carried out
(assuming a 1 compartment model) to investigate the influence of inter-animal variability (in …

Major advances in developing models for pharmacokinetic studies have been made in
recent years, and different approaches can now be employed. These include the use of (1) …

A computer simulation technique used to evaluate the influence of several aspects of
sampling designs on the efficiency of population pharmacokinetic parameter estimation is …

Over the last few decades publication and interest in pharmacokinetics has been greater
than average for scientific subjects (Boxenbaum, 1982a). This growth of interest is probably …

The population approach to pharmacokinetic involves the estimation of mean
pharmacokinetic parameters and their variability within a study population. Advantages of …

The use of statistics in the area of pharmacokinetics comprises, among other things, two
broad categories:(a) estimation techniques to obtain the coefficients of a specified model …