Oxymatrine Protects Chondrocytes against IL‐1β‐triggered Apoptosis in Vitro and Inhibits Osteoarthritis in Mice Model
D Mohetaer, L Cao, Y Wang - … ‐Based Complementary and …, 2022 - Wiley Online Library
Background. Osteoarthritis (OA) is a multifactorial disease with various risk factors, resulting
in the degeneration of articular cartilage and whole joints. However, to date, no effective …
in the degeneration of articular cartilage and whole joints. However, to date, no effective …
Oxymatrine ameliorates osteoarthritis via the Nrf2/NF-κB axis in vitro and in vivo
K Zhou, D Liu, Y Jin, W Xia, P Zhang, Z Zhou - Chemico-Biological …, 2023 - Elsevier
Purpose Osteoarthritis (OA) is a common degenerative joint disorder. Currently, the
underlying etiology of OA is still far from fully elucidated and there is no cure for OA …
underlying etiology of OA is still far from fully elucidated and there is no cure for OA …
Oxymatrine exerts protective effects on osteoarthritis via modulating chondrocyte homoeostasis and suppressing osteoclastogenesis
Y Jiang, W Sang, C Wang, H Lu… - Journal of cellular …, 2018 - Wiley Online Library
Osteoarthritis (OA) is a common degenerative disease characterized by the progressive
destruction both articular cartilage and the subchondral bone. The agents that can effectively …
destruction both articular cartilage and the subchondral bone. The agents that can effectively …
Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
J Lu, J Bian, Y Wang, Y Zhao, X Zhao, G Wang… - Journal of Orthopaedic …, 2024 - Springer
Background Osteoarthritis (OA) is a common degenerative joint disease characterized by
persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine …
persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine …
Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cell balance via the TLR9‐MyD88‐STAT3 signaling pathway
G Cao, Z Mao, T Niu, P Wang, X Yue… - Journal of the …, 2023 - Wiley Online Library
Background Oxymatrine (OMT) is one of the authentic Chinese herbal medicines which has
rich and complex active ingredients. however, the relevant potential targets of oxymatrine on …
rich and complex active ingredients. however, the relevant potential targets of oxymatrine on …
Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling
H Yu, S Yao, C Zhou, F Fu, H Luo, W Du, H Jin… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Corni Fructus (CF), the red fruit of Cornus
officinalis Siebold & Zucc, has been used both as food and medicinal herb in traditional …
officinalis Siebold & Zucc, has been used both as food and medicinal herb in traditional …
Mechanism of oxymatrine in treatment of collagen-induced arthritis in mice
JH Zhan, PP Wang, ZH Cui, XQ Yue… - Zhongguo Zhong yao za …, 2021 - europepmc.org
Sophorae Flavescentis Radix, the root of Sophora flavescens Ait., has been widely applied
in the medical field due to its anti-inflammatory, analgesic, bacteriostatic, antiviral, antitumor …
in the medical field due to its anti-inflammatory, analgesic, bacteriostatic, antiviral, antitumor …
[HTML][HTML] Matrine inhibits IL-1β-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-κB in human chondrocytes in vitro
S Lu, X Xiao, M Cheng - International journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-1β plays an important role in promoting osteoarthritis (OA) lesions by
inducing chondrocytes to secrete matrix metalloproteinases (MMPs), which degrade the …
inducing chondrocytes to secrete matrix metalloproteinases (MMPs), which degrade the …
Anti‑inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells
A Ma, Y Yang, Q Wang, Y Wang… - Molecular …, 2017 - spandidos-publications.com
Oxymatrine (OMT), a monosomic alkaloid extracted from the Chinese herb, Sophora
flavescens Ait, has long been used as a traditional Chinese medicine for the treatment of …
flavescens Ait, has long been used as a traditional Chinese medicine for the treatment of …
Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
Z Li, Z Chen, J Chen, Z Liu, Z Li, H Sun, X Wang… - Chinese Medicine, 2023 - Springer
Background Osteoarthritis (OA) is a chronic degenerative joint disease characterized by loss
of joint function, which seriously reduces the quality of life of the elderly and imposes a …
of joint function, which seriously reduces the quality of life of the elderly and imposes a …