The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the
accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression …

Fig. 1| Aquaporin 4 has direct and indirect roles in controlling fluid flow in the brain. Astrocyte
endfeet wrap around blood vessels at the blood–brain barrier, separated by a cerebrospinal …

The 'glymphatic'system is a brain-wide network of perivascular pathways that supports
exchange of cerebrospinal fluid (CSF) and brain interstitial fluid (ISF), contributing to the …

The blood–brain barrier (BBB), which imposes significant water permeability restriction,
effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the …

The Glymphatic System (GS) has been proposed as a mechanism to clear brain tissue from
waste. Its dysfunction might lead to several brain pathologies, including the Alzheimer's …

The glymphatic system is a low resistance pathway, by which cerebrospinal fluid enters the
brain parenchyma along perivascular spaces via AQP4 channels. It is hypothesised that the …

There is currently a lack of non-invasive tools to assess water transport in healthy and
pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water …

Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

The glymphatic pathway and meningeal lymphatic vessels are involved in clearance of
metabolic macromolecules from the brain. However, the functional interaction between the …