Uterine leiomyomas are the most common tumors of the female genital tract, affecting 50%
to 70% of females by the age of 50. Despite their prevalence and enormous medical and …

Highlights•Leiomyoma cell growth is dependent on ovarian hormone activity through growth
factors.•Growth factors exert their effects activating multiple signal transduction …

Purpose Despite the numerous studies on the factors involved in the genesis and growth of
uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic …

Uterine leiomyomas are benign tumors that originate from the myometrium. Evidence points
to ovarian steroid hormones, in particular, progesterone as major promoters of leiomyoma …

Uterine leiomyomas are a common clinical occurrence for gynecologists. The current
approach to treating these neoplasms is shaped by classic surgical principles and the …

Uterine leiomyomas (fibroids) represent the most common class of benign tumors in women.
Multiple leiomyomas usually arise from the uterus of a symptomatic woman. These tumors …

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

Uterine leiomyomas are common benign smooth muscle tumors that impose a major burden
on women's health. Recent sequencing studies have revealed recurrent and mutually …

Uterine leiomyomas are common and life-altering for many women. Despite a wide range of
symptoms, varying characteristics of the uterus and the leiomyomas themselves, and many …