Cancer genomic instability contributes to the phenomenon of intratumoral genetic
heterogeneity, provides the genetic diversity required for natural selection, and enables the …

Tumor cells typically contain a genome that is highly divergent from the genome of normal,
non-transformed cells. This genetic divergence is caused by a number of distinct changes …

Publisher Summary This chapter discusses the mechanics of genomic instability and the
way the phenotype of genomic instability predisposes to cancer and accelerates tumor …

Human cancers harbour numerous mutations and it has been proposed that these result
from some form of inherent genomic instability. Some cancers have proven genomic …

Genomic instability is a hallmark of cancer that leads to an increase in genetic alterations,
thus enabling the acquisition of additional capabilities required for tumorigenesis and …

Genomic instability has been hypothesized to be a driving force behind multistep
carcinogenesis (Nowell, 1976). A number of genetic changes are required for a normal cell …

Neoplastic cells typically possess numerous genomic lesions, which may include sequence
alterations (point mutations, small deletions, and insertions) and/or gross structural …

Most tumours arise through clonal selection and waves of expansion of a somatic cell that
has acquired genetic alterations in essential genes either controlling cell death or cell …

Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …

Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent
work has strengthened the proposal that mutational alterations conferring instability occur …