Septic shock is mainly characterized—in addition to hypovolemia—by vasoplegia as a
consequence of a release of inflammatory mediators. Systemic vasodilatation due to …

The use of norepinephrine or epinephrine can be left to the discretion of the treating
physician. Low-dose vasopressin administration remains an option for catecholamine …

Background Vasopressin is commonly used as an adjunct to catecholamines to support
blood pressure in refractory septic shock, but its effect on mortality is unknown. We …

Since the publication of the Surviving Sepsis Campaign guidelines, a number of additional
and highly relevant studies have been published addressing the issue of vasopressor use …

Background: Current guidelines recommend norepinephrine as the first-line vasopressor in
septic shock followed by addition of vasopressin to achieve a goal mean arterial pressure …

In addition to fluid resuscitation, the vasopressor therapy is a fundamental treatment of septic
shock-induced hypotension as it aims at correcting the vascular tone depression and then at …

Background Vasopressors are commonly applied to restore and maintain blood pressure in
patients with sepsis. We aimed to evaluate the current practice and therapeutic goals …

BACKGROUND Early goal-directed therapy is a time-sensitive therapeutic algorithm with a
tiered approach to target hypoperfusion and cardiovascular collapse within the first 6 hours …

Methods: We selected studies in adults with septic shock that compared the outcomes of
patients treated with vasopressin versus norepinephrine. Cochrane ROB 2.0 and the …

Vasopressor therapy is one of the cornerstones in the management of septic shock when
intravenous fluid resuscitation is insufficient to maintain a mean arterial pressure (MAP) …