In treating eye diseases, topical administration on the ocular surface is the most convenient
and acceptable route. However, the intraocular efficiency of non-invasive drug delivery …

The aim of this study was to develop and characterize a novel colloidal system, namely,
timolol maleate chitosan coated liposomes (TM-CHL) to enhance the ocular permeation …

The topically administered glaucoma medications usually encounter serious precorneal
drug loss and low corneal penetration, leading to a low bioavailability. In addition, due to the …

The objective of this study was to develop an ocular drug delivery system built on the
cationic liposomes, a novel bioadhesive colloidal system, which could enhance the …

In this study, novel chitosan-coated deformable liposomes (DL-CS) were proposed as an
ocular drug delivery system to prolong pre-corneal retention, and improve transcorneal …

Topical route of administration is the most commonly used method for the treatment of
ophthalmic diseases. However, presence of several layers of permeation barriers starting …

Topical ophthalmologic treatments have been facing great challenges with main limitations
of low drug bioavailability, due to highly integrative defense mechanisms of the eye. This …

Topical instillation is the most widely preferred noninvasive route of drug administration to
treat diseases affecting the anterior segment of the eye. Nonetheless, the ocular …

Effective drug delivery to intraocular tissues remains a great challenge due to complex
anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To …

Liposomes are promising spherical vesicles for topical drug delivery to the eye. Several
types of vesicles were formulated in this study, including conventional, PEGylated, and …