Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

Objective: We aimed at summarizing current evidence about mechanisms for potentially
harmful effects of Proton Pump Inhibitors (PPIs). Methods: A Pubmed search was performed …

Despite the dramatic success of pharmacological acid suppression in healing peptic ulcers
(PUs) and managing patients with gastro-esophageal reflux disease (GERD) a number of …

Gastric acid is pathogenic in many gastrointestinal disorders, such as gastroesophageal
reflux disease and peptic ulcer disease. Proton pump inhibitors (PPIs) are the antisecretory …

Introduction: The introduction of proton pump inhibitors (PPIs) into clinical practice has
greatly improved our therapeutic approach to acid-related diseases for their efficacy and …

Proton pump inhibitors have become the mainstay of medical treatment of acid-related
disorders. Long-term use is becoming increasingly common, in some cases without a proper …

Proton pump (H+/K+–adenosine triphosphatase) inhibitors (PPIs) are widely used to treat
patients with acid-related disorders because they are generally perceived to be safe and …

Abstract Proton Pump Inhibitors (PPIs) are widely used in the treatment of acid-peptic
diseases. Their mechanism of action involves inhibition of the HK-adenosine triphosphatase …

Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have
since proven to be invaluable, safe, and effective agents for the management of a variety of …

Proton pump inhibitors (PPI) are very effective drugs used largely in acid related disorders.
During the last years concern have been raised regarding their overutilisation in benign …