Objective To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by
investigating differential brain patterns of gray and white matter involvement in clinically or …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

Now that genetic testing can identify persons at risk for developing amyotrophic lateral
sclerosis (ALS) many decades before symptoms begin, there is a critical need for …

Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …

Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …

Objective C9orf72 mutation carriers with different neurological phenotypes show cortical and
subcortical atrophy in multiple different brain regions, even in pre-symptomatic phases …

Objectives: To characterize the nature and extent of basal ganglia involvement in
amyotrophic lateral sclerosis (ALS) genotypes in vivo. Methods: Forty-four healthy controls …

Importance Presymptomatic carriers of chromosome 9 open reading frame 72 (C9orf72)
mutation, the most frequent genetic cause of frontotemporal lobar degeneration and …

ObjectiveAdvanced neuroimaging techniques may offer the potential to monitor disease
progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative, multisystem …

Objective To discern presymptomatic changes in brain structure or function using advanced
MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). Methods T1 …