Genetics of kidney stone disease
SA Howles, RV Thakker - Nature Reviews Urology, 2020 - nature.com
Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …
The genetics of kidney stone disease and nephrocalcinosis
P Singh, PC Harris, DJ Sas, JC Lieske - Nature Reviews Nephrology, 2022 - nature.com
Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …
Progress in understanding the genetics of calcium-containing nephrolithiasis
JA Sayer - Journal of the American Society of Nephrology, 2017 - journals.lww.com
Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …
globally. Calcium-based calculi account for around 75% of renal stone disease and the …
Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis
J Halbritter, M Baum, AM Hynes, SJ Rice… - Journal of the …, 2015 - journals.lww.com
Nephrolithiasis is a prevalent condition with a high morbidity. Although dozens of
monogenic causes have been identified, the fraction of single-gene disease has not been …
monogenic causes have been identified, the fraction of single-gene disease has not been …
Kidney stones: pathophysiology and medical management
OW Moe - The lancet, 2006 - thelancet.com
The formation of stones in the urinary tract stems from a wide range of underlying disorders.
That clinicians look for the underlying causes for nephrolithiasis is imperative to direct …
That clinicians look for the underlying causes for nephrolithiasis is imperative to direct …
[HTML][HTML] Genetics of hypercalciuric stone forming diseases
O Devuyst, Y Pirson - Kidney international, 2007 - Elsevier
With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major
health problem worldwide. Approximately, 80% of kidney stones are composed of calcium …
health problem worldwide. Approximately, 80% of kidney stones are composed of calcium …
[HTML][HTML] Genetics and calcium nephrolithiasis
G Vezzoli, A Terranegra, T Arcidiacono, L Soldati - Kidney international, 2011 - Elsevier
Calcium nephrolithiasis is one of the most prevalent uronephrologic disorders in the western
countries. Studies in families and twins evidenced a genetic predisposition to calcium …
countries. Studies in families and twins evidenced a genetic predisposition to calcium …
Genetic determinants of urolithiasis
CG Monico, DS Milliner - Nature Reviews Nephrology, 2012 - nature.com
Urolithiasis affects approximately 10% of individuals in Western societies by the seventh
decade of life. The most common form, idiopathic calcium oxalate urolithiasis, results from …
decade of life. The most common form, idiopathic calcium oxalate urolithiasis, results from …
[HTML][HTML] Genetic variants of calcium and vitamin D metabolism in kidney stone disease
SA Howles, A Wiberg, M Goldsworthy… - Nature …, 2019 - nature.com
Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a
heritability of~ 45–60%. We present genome-wide association studies in British and …
heritability of~ 45–60%. We present genome-wide association studies in British and …
[HTML][HTML] Common and rare variants associated with kidney stones and biochemical traits
Kidney stone disease is a complex disorder with a strong genetic component. We conducted
a genome-wide association study of 28.3 million sequence variants detected through whole …
a genome-wide association study of 28.3 million sequence variants detected through whole …