Major depressive disorder (MDD) is a complex mood disorder. While much progress has
been made in understanding the pathophysiology of MDD, no single mechanism can …

The present paper aims at reviewing and commenting on the relationships between sleep
and circadian phasing alterations and neurodegenerative/neuroprogressive processes in …

Mammalian physiology and behavior are regulated by an internal time-keeping system,
referred to as circadian rhythm. The circadian timing system has a hierarchical organization …

Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading
cause of disability, affecting approximately 100 million adults worldwide. The disorder is …

The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical
practice, may arise from a variety of psychiatric disorders, most importantly depression. Even …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

The prevalence of mood disorders in the population is the highest among the diagnosed
mental illnesses. In the US, an estimated 21.4% of adults have experienced a clinically …

Sleep disturbance is the most prominent symptom in depressive patients and was formerly
regarded as a main secondary manifestation of depression. However, many longitudinal …

Affective disorders such as major depression, bipolar disorders and seasonal affective
disorders have been described as alterations of various neuronal systems. In addition to the …

In depression, symptoms range from loss of motivation and energy to suicidal thoughts.
Moreover, in depression alterations might be also observed in the sleep-wake cycle and in …