Disrupted prefrontal neuronal oscillations and morphology induced by sleep deprivation in young APP/PS1 transgenic AD mice

S Tabassum, A Misrani, S Tabassum, A Ahmed… - Brain Research …, 2021 - Elsevier
Emerging evidence suggests that sleep deprivation (SD) is a public health epidemic and
increase the risk of Alzheimer's disease (AD) progression. However, the underlying …

Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP/PS1 transgenic mice

C Wang, WR Gao, J Yin, ZJ Wang, JS Qi, HY Cai… - Behavioural Brain …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive deficits. Sleep deprivation (SD) could lead to memory deficits, and it was a …

Comparison between sub-chronic and chronic sleep deprivation-induced behavioral and neuroimmunological abnormalities in mice: focusing on glial cell phenotype …

NUK Niazi, C Huang, Z Yang, Y Zhang… - Behavioural Brain …, 2024 - Elsevier
Background Sleep disorders, depression, and Alzheimer's disease (AD) are extensively
reported as comorbidity. Although neuroinflammation triggered by microglial phenotype M1 …

Chronic sleep disturbances alters sleep structure and tau phosphorylation in AβPP/PS1 AD mice and their wild-type littermates

F Zhang, L Niu, R Zhong, S Li… - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Emerging evidence indicates that sleep disorders are the common non-
cognitive symptoms of Alzheimer's disease (AD), and they may contribute to the …

[HTML][HTML] Insights from human sleep research on neural mechanisms of Alzheimer's disease

S Cordone, L De Gennaro - Neural Regeneration Research, 2020 - journals.lww.com
Alzheimer's disease (AD) is considered as the major cause of dementia and affects about 50
million people in world population, with an expected increase of 27% in the coming …

[HTML][HTML] Reduced slow-wave activity and autonomic dysfunction during sleep precede cognitive deficits in Alzheimer's disease transgenic mice

CW Chen, YT Kwok, YT Cheng, YS Huang, TBJ Kuo… - Scientific reports, 2023 - nature.com
Occurrence of amyloid-β (Aβ) aggregation in brain begins before the clinical onset of
Alzheimer's disease (AD), as preclinical AD. Studies have reported that sleep problems and …

[HTML][HTML] Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits

J Van Erum, D Van Dam, R Sheorajpanday… - Behavioural Brain …, 2019 - Elsevier
Abstract Alzheimer's disease (AD), which accounts for most of the dementia cases, is, aside
from cognitive deterioration, often characterized by the presence of non-cognitive symptoms …

Chronic sleep deprivation exacerbates learning-memory disability and Alzheimer's disease-like pathologies in AβPP swe/PS1 Δ E9 Mice

H Qiu, R Zhong, H Liu, F Zhang, S Li… - Journal of Alzheimer's …, 2016 - content.iospress.com
Recently, there is an increasing concern over the association between sleep disorders and
Alzheimer's disease (AD). Clinical observations have reported that chronic sleep deprivation …

Sleep deprivation accelerates the progression of Alzheimer's disease by influencing Aβ-related metabolism

L Chen, J Huang, L Yang, XA Zeng, Y Zhang… - Neuroscience …, 2017 - Elsevier
Sleep disorders have previously been connected with the neurodegenerative pathology of
Alzheimer's disease (AD) due to the aggregation of β-amyloid (Aβ) peptides and tau …

[HTML][HTML] Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease

J Cedernaes, RS Osorio, AW Varga, K Kam… - Sleep medicine …, 2017 - Elsevier
During wakefulness, extracellular levels of metabolites in the brain increase. These include
amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer's disease (AD) …