Abstract Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing
enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral …

Abstract Carboxylesterase 1 (CES1), a member of the serine hydrolase superfamily, is
involved in a wide range of xenobiotic and endogenous substances metabolic reactions in …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …

Abstract The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several
enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate …

Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity.
Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of …

Abstract Human carboxylesterase 2A (hCES2A), the most abundant carboxylesterase in the
human gut, plays a crucial role in the metabolic clearance and activation of various ester …

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …

Abstract Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity.
Here, we performed activity-based protein profiling to assess the functional level of serine …