There is a growing number of biomolecules, including peptides, proteins, monoclonal
antibodies and RNA, that could be potentially used for the treatment of central nervous …

Abstract Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to
reach the brain in a non-invasive way. This article is a comprehensive review of the state-of …

Direct nose-to-brain (N-to-B) delivery enables the rapid transport of drugs to the brain, while
minimizing systemic exposure. The objective of this work was to engineer a nanocarrier …

Due to their high specificity toward the target and their low toxicity, biological drugs have
been successfully employed in a wide range of therapeutic areas. It is yet to be mentioned …

Introduction: Among the range of therapeutic protein candidates for new generation
treatments of neurological diseases, neurotrophic factors and recombinant antibodies hold …

Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration,
chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would …

Proteins and hormones have a wide range of therapeutic uses that have emerged
throughout the years. The increase in their clinical application nowadays has outgrown the …

Intranasal drug delivery is emerging as a reliable and promising pathway to deliver a wide
range of therapeutic agents including small and large molecules, peptides and proteins …

The current therapeutic strategies are not efficient in treating disorders related to the central
nervous system (CNS) and have only shown partial alleviation of symptoms, as opposed to …

Brain delivery of macromolecular therapeutics (eg., proteins) remains an unsolved problem
because of the formidable blood–brain barrier (BBB). Although a direct pathway of nose-to …