Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

After the resolution of an immune response, antigen-specific memory T cells persist at many
sites in the body. The antigen-specific memory T-cell pool includes memory T cells that …

Tissues such as the genital tract, skin, and lung act as barriers against invading pathogens.
To protect the host, incoming microbes must be quickly and efficiently controlled by the …

Intensified efforts to promote protective T cell-based immunity in vaccines and
immunotherapies have created a compelling need to expand our understanding of human T …

In response to infection, naive CD 4+ T‐cells proliferate and differentiate into several
possible effector subsets, including conventional T helper effector cells (TH 1, TH 2, TH 17) …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Changes in T cell trafficking accompany the naive to memory T cell antigen-driven
differentiation, which remains an incompletely defined developmental step. Upon priming …

T cell immunity has long been described in terms of two circulating memory populations.
Central memory T (T CM) cells migrate between the secondary lymphoid organs and are …

Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their
distribution and function in tissues remains largely unknown. Here, we present a unique …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …