Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

Typical mass spectrometry (MS) based untargeted metabolomics protocols are tedious as
well as time-and sample-consuming. In particular, they often rely on “full-scan-only” …

Highlights•We review high-throughput mass spectrometry-based methods for metabolomic
analysis.•High-throughput approaches usually improve throughput at the expense of …

Recent advances in mass spectrometry are enabling improved analysis of endogenous
metabolites. Here we discuss several issues relevant to developing liquid chromatography …

Metabolomics is a technique in which the small molecule component from a biological
source material is analyzed for changes resulting from some set of test conditions. Liquid …

Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic
changes taking place in biological systems under different conditions. By its nature, this is a …

The present review gives an introduction into the concept of metabolomics and provides an
overview of the analytical tools applied in non-targeted metabolomics with a focus on liquid …