Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis

P Damdimopoulou, C Chiang, JA Flaws - Reproductive Toxicology, 2019 - Elsevier
Retinoids are essential for reproduction. Most research has focused on the role of retinoic
acid signaling in the regulation of meiosis during early fetal germ cell development …

Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary

Z Liu, Y Sun, Y Jiang, Y Qian, S Chen, S Gao… - Reproductive Biology …, 2018 - Springer
Background Retinoids (retinol and its derivatives) are required for the development and
maintenance of normal physiological functions of the ovary. However, the mechanisms …

Segregation of Retinoic Acid Effects on Fetal Ovarian Germ Cell Mitosis Versus Apoptosis by Requirement for New Macromolecular Synthesis

Y Morita, JL Tilly - Endocrinology, 1999 - academic.oup.com
Retinoic acid (RA), a naturally occurring metabolite of vitamin A, plays an essential role in
regulating cellular growth, differentiation, and death in a variety of tissues, particularly during …

Potential role of retinoids in ovarian physiology and pathogenesis of polycystic ovary syndrome

Y Jiang, C Li, L Chen, F Wang, X Zhou - Clinica chimica acta, 2017 - Elsevier
Retinoids (retinol and its derivatives) are required for maintaining vision, immunity, barrier
function, reproduction, embryogenesis, cell proliferation and differentiation. Furthermore …

Function of retinoic acid in development of male and female gametes

MC Schleif, SL Havel, MD Griswold - Nutrients, 2022 - mdpi.com
Retinoic acid, an active metabolite of vitamin A, is necessary for many developmental
processes in mammals. Much of the field of reproduction has looked toward retinoic acid as …

[HTML][HTML] Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha

DJ Wolgemuth, SSW Chung - Society of Reproduction and Fertility …, 2007 - ncbi.nlm.nih.gov
The importance of dietary retinol (vitamin A) and retinoid signaling for normal development
and differentiation has been recognised for many years. Vitamin A deficiency results in a …

Retinoic acid signaling determines the fate of the uterus from the mouse Müllerian duct

T Nakajima, T Sato, T Iguchi, N Takasugi - Reproductive toxicology, 2019 - Elsevier
In female mice, the Müllerian duct develops into the oviduct, uterus and vagina. The fate of
epithelia is determined by factors secreted from the mesenchyme. Retinoic acid (RA) and its …

Adverse effects of retinoic acid on embryo development and the selective expression of retinoic acid receptors in mouse blastocysts

FJ Huang, YD Hsuuw, KC Lan, HY Kang… - Human …, 2006 - academic.oup.com
BACKGROUND: All-trans retinoic acid (RA), the oxidative metabolite of vitamin A, is
essential for normal development. In addition, high levels of RA are teratogenic in many …

Retinoic acid inhibits rat XY gonad development by blocking mesonephric cell migration and decreasing the number of gonocytes

H Li, KH Kim - Biology of reproduction, 2004 - academic.oup.com
Vitamin A (also called retinol) and its derivatives, retinoic acids (RAs), are required for
postnatal testicular function. Abnormal spermatogenesis is observed in rodents on vitamin A …

Retinoic acid in developmental toxicology: teratogen, morphogen and biomarker

AH Piersma, EV Hessel, YC Staal - Reproductive toxicology, 2017 - Elsevier
This review explores the usefulness retinoic acid (RA) related physiological factors as
possible biomarkers of embryotoxicity. RA is involved in the morphogenesis of the early …