Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …

The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional
longevity. Materials & methods: Participants were from three adult cohorts with blood DNA …

In this review, we summarize current knowledge regarding the epigenetics of age-related
diseases, focusing on those studies that have described DNA methylation landscape in …

Background The epigenetic clock, in particular epigenetic pre-aging quantified by the so-
called DNA methylation age acceleration, has recently been suggested to closely correlate …

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …

Gender accounts for important differences in the incidence and prevalence of a variety of
age-related diseases. Considering people of far advanced age, demographic data …

Many epidemiological data indicate the presence of a strong familial component of longevity
that is largely determined by genetics, and a number of possible associations between …

Over the past two decades, a growing interest on the research of the biological basis of
human longevity has emerged, in order to clarify the intricacy of biological and …

Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …