Objective Osteoporosis is associated with senescence of bone marrow mesenchymal stem
cells (BMSCs). Extracellular vesicles derived from senescent BMSCs (BMSC-EVs) could be …

Background Muscle atrophy due to disuse occurs along with adverse physiological and
functional changes, but bone marrow stromal cells (MSCs) may be able to act as muscle …

Background Sarcopenia is a common and progressive skeletal muscle disorder
characterized by atrophic muscle fibres and contractile dysfunction. Accumulating evidence …

Background Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the
musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative …

Sarcopenia is a common age-related skeletal muscle disorder featuring the loss of muscle
mass and function. In regard to tissue repair in the human body, scientists always consider …

Osteoporosis, or steroid-induced osteonecrosis of the hip, is accompanied by increased
bone marrow adipogenesis. Such a disorder of adipogenic/osteogenic differentiation …

Background Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate
osteogenesis or excessive adipogenesis as they age due to changes in the bone …

Aims Mouse bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells with self-
renewal and differentiation abilities. Since the effects of senescent BMSCs on C2C12 cells …

With the expansion of the aging population, age-associated sarcopenia (AAS) has become
a severe clinical disease of the elderly and a key challenge for healthy aging. Regrettably …

Tissue-resident stem cell senescence leads to stem cell exhaustion, which is a major cause
of physiological and pathological ageing. Stem cell-derived extracellular vesicles (SC-EVs) …