Age-related neurodegenerative diseases are a growing burden to society, and many are
sporadic, meaning that the environment, diet and lifestyle play significant roles …

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

The glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout
the brain, responsible for replenishing as well as cleansing the brain. Glymphatic clearance …

This paper delves into the intricate structure and functionality of the brain's glymphatic
system, bringing forth new dimensions in its neuroscientific understanding. This paper …

The brain's high bioenergetic state is paralleled by high metabolic waste production.
Authentic lymphatic vasculature is lacking in brain parenchyma. Cerebrospinal fluid (CSF) …

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

The cerebral vasculature serves as the crossroads of the CNS, supporting exchange of
nutrients, metabolic wastes, solutes and cells between the compartments of the brain …

The glymphatics system describes a CSF-mediated clearance pathway for the removal of
potentially harmful molecules, such as amyloid beta, from the brain. As such, its components …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …