Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?

TC Saat, EK van den Akker, JNM IJzermans… - Journal of translational …, 2016 - Springer
Kidney transplantation is the treatment of choice in patients with end stage renal disease.
During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor …

Managing renal transplant ischemia reperfusion injury: novel therapies in the pipeline

JT Powell, DS Tsapepas, ST Martin… - Clinical …, 2013 - Wiley Online Library
Ischemia reperfusion injury (IRI) is an early, non‐specific inflammatory response that follows
perfusion of warm blood into a cold asanguinous organ following transplantation. The …

Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond

H Zhao, A Alam, AP Soo, AJT George, D Ma - EBioMedicine, 2018 - thelancet.com
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …

[HTML][HTML] Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment

M Salvadori, G Rosso, E Bertoni - World journal of transplantation, 2015 - ncbi.nlm.nih.gov
Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention

M Kosieradzki, W Rowiński - Transplantation proceedings, 2008 - Elsevier
Ischemia has been an inevitable event accompanying kidney transplantation. Ischemic
changes start with brain death, which is associated with severe hemodynamic disturbances …

Ischemia and reperfusion injury in kidney transplantation: relevant mechanisms in injury and repair

GJ Nieuwenhuijs-Moeke, SE Pischke… - Journal of clinical …, 2020 - mdpi.com
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

Biological modulation of renal ischemia–reperfusion injury

MGJ Snoeijs, LWE van Heurn… - Current opinion in organ …, 2010 - journals.lww.com
We conclude that the pathophysiology of delayed graft function after kidney transplantation
is complex and shares broad similarity with rodent models of ischemic acute kidney injury …

Thrombin inhibition during kidney ischemia-reperfusion reduces chronic graft inflammation and tubular atrophy

R Thuillier, F Favreau, O Celhay, L Macchi… - …, 2010 - journals.lww.com
Background. Ischemia-reperfusion injury (IRI) is an unavoidable component of
transplantation and correlates with delayed graft function, acute rejection, chronic fibrosis …

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

C Ponticelli - Nephrology Dialysis Transplantation, 2014 - academic.oup.com
Ischaemia-reperfusion injury (IRI) is a frequent event in kidney transplantation, particularly
when the kidney comes from a deceased donor. The brain death is usually associated with …

Renal ischaemia reperfusion injury: a mouse model of injury and regeneration

EE Hesketh, A Czopek, M Clay, G Borthwick… - JoVE (Journal of …, 2014 - jove.com
Renal ischaemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) in
patients and occlusion of renal blood flow is unavoidable during renal transplantation …