Aging is characterized by the progressive deregulation of homeostatic mechanisms causing
the accumulation of macromolecular damage, including DNA damage, progressive decline …

Defects in the DNA damage response and repair (DDR/R) network accumulate during the
aging process. Physical frailty, a state of reduced physiological function and decreased …

Background Accumulation of DNA damage leading to adult stem cell exhaustion has been
proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy …

Age-related DNA damage has been regarded as one of the possible explanations of aging,
and these age-related changes have been associated with lifestyle variables. Considering …

Recent advances have identified accumulation of DNA damage as a major driver of aging.
However, there are numerous kinds of DNA lesions each with their own characteristics and …

Cellular aging is characterized by telomere shortening, which can lead to uncapping of
chromosome ends (telomere dysfunction) and activation of DNA damage responses. There …

Age-related DNA damage is regarded as one of the possible explanations of aging.
Although a generalized idea about the accumulation of DNA damage with age exists, results …

It has been hypothesised that positive associations between age and levels of oxidative
stress-generated damage to DNA may be related to an age-dependent decline in DNA …

Maintenance of tissue-specific stem cells is vital for organ homeostasis and organismal
longevity. Hematopoietic stem cells (HSCs) are the most primitive cell type in the …

Aging is associated with oxidative stress-generated damage to DNA and this could be
related to metabolic disturbances. This study investigated the association between levels of …