HPV sequencing facilitates ultrasensitive detection of HPV circulating tumor DNA

E Leung, K Han, J Zou, Z Zhao, Y Zheng, TT Wang… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: Human papillomavirus (HPV) DNA offers a convenient circulating tumor
DNA (ctDNA) marker for HPV-associated malignancies, but current methods, such as digital …

Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse

S Mittelstadt, O Kelemen, J Admard… - British Journal of …, 2023 - nature.com
Background HPV-related cervical cancer (CC) is the fourth most frequent cancer in women
worldwide. Cell-free tumour DNA is a potent biomarker to detect treatment response …

A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization

X Sastre-Garau, M Diop, F Martin, G Dolivet… - Clinical Cancer …, 2021 - AACR
Purpose: Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low
number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated …

Circulating HPV DNA in the management of oropharyngeal and cervical cancers: current knowledge and future perspectives

E Krasniqi, M Barba, A Venuti, L Pizzuti… - Journal of Clinical …, 2021 - mdpi.com
Human papillomaviruses (HPVs) are associated with invasive malignancies, including
almost 100% of cervical cancers (CECs), and 35–70% of oropharyngeal cancers (OPCs) …

Circulating cell-free DNA for metastatic cervical cancer detection, genotyping, and monitoring

Z Kang, S Stevanović, CS Hinrichs, L Cao - Clinical Cancer Research, 2017 - AACR
Purpose: Circulating cell-free (ccf) human papillomavirus (HPV) DNA may serve as a unique
tumor marker for HPV-associated malignancies, including cervical cancer. We developed a …

HPV circulating tumoral DNA quantification by droplet‐based digital PCR: a promising predictive and prognostic biomarker for HPV‐associated oropharyngeal …

D Veyer, M Wack, M Mandavit… - … journal of cancer, 2020 - Wiley Online Library
We aimed to determine whether pretherapeutic assessment of HPV circulating tumoral DNA
(HPV ctDNA) by droplet‐based digital PCR (ddPCR) could constitute a predictive and …

Detection of circulating HPV16 DNA as a biomarker for cervical cancer by a bead-based HPV genotyping assay

L Galati, JD Combes, F Le Calvez-Kelm… - Microbiology …, 2022 - Am Soc Microbiol
Human papillomavirus (HPV) circulating tumor DNA (HPV ctDNA) was proposed as a
biomarker for the detection and disease monitoring of HPV-related cancers. One hundred …

Development of a high-performance multi-probe droplet digital PCR assay for high-sensitivity detection of human papillomavirus circulating tumor DNA from plasma

C Bhambhani, E Sandford, CT Haring, C Brummel… - Oral Oncology, 2023 - Elsevier
Objectives To develop a high-performance droplet digital PCR (ddPCR) assay capable of
enhancing the detection of human papillomavirus (HPV) circulating tumor DNA (ctDNA) in …

Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV‐positive head and neck cancer

EM Rettig, DL Faden, S Sandhu… - … Journal of Cancer, 2022 - Wiley Online Library
Human papillomavirus (HPV), most commonly HPV16, causes a growing subset of head
and neck squamous cell carcinomas (HNSCCs), including the overwhelming majority of …

The current status of cell‐free human papillomavirus DNA as a biomarker in cervical cancer and other HPV‐associated tumors: A review

L Sivars, K Palsdottir… - … Journal of Cancer, 2023 - Wiley Online Library
Tumor cells release fragments of their DNA into the circulation, so called cell‐free tumor
DNA (ctDNA), allowing for analysis of tumor DNA in a simple blood test, that is, liquid biopsy …