Rapid structure determination of microcrystalline molecular compounds using electron diffraction
T Gruene, JTC Wennmacher… - Angewandte Chemie …, 2018 - Wiley Online Library
Chemists of all fields currently publish about 50 000 crystal structures per year, the vast
majority of which are X‐ray structures. We determined two molecular structures by …
majority of which are X‐ray structures. We determined two molecular structures by …
Structure determination of small molecule compounds by an electron diffractometer for 3D ED/MicroED
S Ito, FJ White, E Okunishi, Y Aoyama, A Yamano… - …, 2021 - pubs.rsc.org
3D electron diffraction (3D ED)/Micro electron diffraction (MicroED) has extended the limits
of crystallography by enabling the determination of three dimensional molecular structures …
of crystallography by enabling the determination of three dimensional molecular structures …
Establishing electron diffraction in chemical crystallography
T Gruene, JJ Holstein, GH Clever… - Nature Reviews Chemistry, 2021 - nature.com
The emerging field of 3D electron diffraction (3D ED) opens new opportunities for structure
determination from sub-micrometre-sized crystals. Although the foundations of this …
determination from sub-micrometre-sized crystals. Although the foundations of this …
The collection of MicroED data for macromolecular crystallography
D Shi, BL Nannenga, MJ De La Cruz, J Liu… - Nature …, 2016 - nature.com
The formation of large, well-ordered crystals for crystallographic experiments remains a
crucial bottleneck to the structural understanding of many important biological systems. To …
crucial bottleneck to the structural understanding of many important biological systems. To …
Electron diffraction of 3D molecular crystals
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …
enabled counterpart. Recent advances in data collection and analysis have sparked a …
The cryo-EM method microcrystal electron diffraction (MicroED)
BL Nannenga, T Gonen - Nature methods, 2019 - nature.com
In 2013 we established a cryo-electron microscopy (cryo-EM) technique called microcrystal
electron diffraction (MicroED). Since that time, data collection and analysis schemes have …
electron diffraction (MicroED). Since that time, data collection and analysis schemes have …
The crystal structure of orthocetamol solved by 3D electron diffraction
I Andrusenko, V Hamilton, E Mugnaioli… - Angewandte Chemie …, 2019 - Wiley Online Library
Orthocetamol is a regioisomer of the well‐known pain medication paracetamol and a
promising analgesic and an anti‐arthritic medicament itself. However, orthocetamol cannot …
promising analgesic and an anti‐arthritic medicament itself. However, orthocetamol cannot …
3D electron diffraction for chemical analysis: Instrumentation developments and innovative applications
T Gruene, E Mugnaioli - Chemical Reviews, 2021 - ACS Publications
In the past few years, many exciting papers reported results based on crystal structure
determination by electron diffraction. The aim of this review is to provide general and …
determination by electron diffraction. The aim of this review is to provide general and …
[HTML][HTML] Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery
C Vénien-Bryan, Z Li, L Vuillard… - … Section F: Structural …, 2017 - scripts.iucr.org
The invention of the electron microscope has greatly enhanced the view scientists have of
small structural details. Since its implementation, this technology has undergone …
small structural details. Since its implementation, this technology has undergone …
[PDF][PDF] MicroED with the Falcon III direct electron detector
Microcrystal electron diffraction (MicroED) combines crystallography and electron cryo-
microscopy (cryo-EM) into a method that is applicable to high-resolution structure …
microscopy (cryo-EM) into a method that is applicable to high-resolution structure …