[HTML][HTML] Prospects for the production of recombinant therapeutic proteins and peptides in plants: Special focus on Angiotensin I-Converting Enzyme Inhibitory (ACEI) …

C Gomes, F Oliveira, SI Vieira… - Genetic engineering-A …, 2019 - intechopen.com
Molecular pharming is a cost-effective, scalable, and safe system to produce high-quality
and biologically active recombinant therapeutic proteins. Thus, plants are emerging …

Current genetic engineering strategies for the production of antihypertensive ACEI peptides

C Gomes, D Ferreira, JPF Carvalho… - Biotechnology and …, 2020 - Wiley Online Library
Hypertension is a major and highly prevalent risk factor for various diseases. Among the
most frequently prescribed antihypertensive first‐line drugs are synthetic angiotensin I …

Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from plants

C Daskaya-Dikmen, A Yucetepe, F Karbancioglu-Guler… - Nutrients, 2017 - mdpi.com
Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting
enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE …

Plant food-derived angiotensin I converting enzyme inhibitory peptides

C Guang, RD Phillips - Journal of Agricultural and Food Chemistry, 2009 - ACS Publications
Hypertension is one of the most common worldwide diseases that afflict humans.
Angiotensin I converting enzyme (ACE) catalyzes the formation of vasoconstrictor …

Biotechnological production of the angiotensin‐converting enzyme inhibitory dipeptide isoleucine‐tryptophan

L Michelke, A Deussen, K Kettner… - Engineering in Life …, 2018 - Wiley Online Library
Peptides with angiotensin‐converting enzyme (ACE)‐inhibitory and antihypertensive effects
are suggested as innovative food additives to prevent or treat hypertension. Currently, these …

Production of active angiotensin‐I converting enzyme inhibitory peptides derived from bovine β‐casein by recombinant DNA technologies

M Losacco, R Gallerani, M Gobbetti… - Biotechnology …, 2007 - Wiley Online Library
A wide range of anti‐hypertensive peptides potentially able to lower blood pressure through
the inhibition of vasoactive enzymes such as angiotensin‐I converting enzyme (ACE) are …

Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production

BA Murray, RJ FitzGerald - Current pharmaceutical design, 2007 - ingentaconnect.com
Food proteins contain latent biofunctional peptide sequences within their primary structures
which may have the ability to exert a physiological response in vivo. A large range of …

Review on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins

HL He, D Liu, CB Ma - Applied Biochemistry and Biotechnology, 2013 - Springer
Hypertension is now a major problem threatening people health in the world. Angiotensin-I-
converting enzyme (ACE) plays an important physiological role in regulation of blood …

Angiotensin converting enzyme (ACE) inhibitory peptides: production and implementation of functional food

F De Leo, S Panarese, R Gallerani… - Current pharmaceutical …, 2009 - ingentaconnect.com
In recent decades, the most successful strategy for controlling blood pressure has been
inhibition of the angiotensin-converting enzyme (ACE). ACE inhibitors of chemical synthesis …

Anti-hypertensive peptides derived from caseins: mechanism of physiological action, production bioprocesses, and challenges for food applications

MR de Oliveira, TJ Silva, E Barros… - Applied biochemistry …, 2018 - Springer
This review is focused on the state-of-art of peptides with inhibitory activity towards
angiotensin I-converting enzyme (ACE)—thus, with anti-hypertensive potential—derived …